This special issue of the Industrial and Systems Engineering Review highlights top papers from the 2020 Annual General Donald R. Keith memorial capstone conference held at the United States Military Academy in West Point, NY. The conference was certainly a first of its kind virtual conference including asynchronous delivery of paper presentations followed by synchronous question and answer sessions with evaluation panels. Following careful review of 63 total submissions, eleven were selected for publication in this journal. Unique to this year’s special edition is the mixed selection of seven project team capstone papers, and four honors research papers. Each paper incorporated features of systems or industrial engineering and presented detailed and reflective analysis on the topic. Although there are many elements which cut across the works, three general bodies of knowledge emerged in the papers including: systems engineering and decision analysis, systems design, modeling and simulation, and system dynamics.